Mend, rethink, transform, recreate! Mending your favorite fabric items--from jeans to sweaters to sofa covers--becomes a true art form in Creative Mending. In this book, mending guru Hikaru Noguchi shows you her entire range of valuable techniques--from embroidery and patching to darning and felting--that are just challenging enough for experienced menders. Noguchi's basic rules of mending are that the repair should suit the fabric and its user, and that there are lots of creative ways to create beautifully customized repairs--some subtle, others making a statement. She provides 13 techniques that show you how to: Apply creative repairs to both knitted and woven fabrics Use yarn, floss, ribbon, and fabric to reinvent well-loved garments Make understated repairs that add just a touch of contrast, color, or texture Use visible mending techniques for bold repairs Darn with felt to add body and dimension to a repaired item Match your repairs to the damage, the fabric, and the wearer Maneuver through tricky places like inseams and underarms And more! The 13 illustrated lessons and over 300 color photos in this book provide detailed examples for all the basic techniques. Lots of variations plus plenty of tips and examples (67 in all) provide you with all the guidance you need to rethink and repair beautifully. The stunning photos will inspire you to get creative on that fraying neckline or worn elbow!

This is the first UK edition of the cult darning book by Hikaru Noguchi who has become a guru of visible darning in Japan. With 12 different darning techniques and 63 inspirational examples, this detailed step by step guide makes the methods easy to follow. The stylish photography shows off the artistic and minimalist style of the designer's work.

This book proposes a new paradigm for English language teaching based on concepts from English for Specific Purposes (ESP) research and applications as well as from growing evidence relating pattern recognition to language learning ability. The contributors to the volume argue that learners should not try to become proficient all-around users of 'idealistic native-like' English, but instead should be realistic about what they need to acquire and how to go about achieving their specific goals. The book discusses the present situation by describing the status quo of English language education in Japan, taking into consideration recent trends of CLIL (content and language integrated learning), EMI (English medium instruction), and TBLT (task-based language teaching) as well as the work done on the Common European Framework of Reference for Languages (CEFR). It introduces new movements in ESP in Japan and in other Asian regions, covering topics ranging from genre analysis to corpus linguistics, and presents application examples of ESP practice in a range of educational situations in Japan from the graduate school level to elementary and middle school contexts. It also offers readers application examples of ESP practice in a range of business settings and expands the discussion to the global sphere where EAP and ESP are gaining importance as the number of ELF (English as a Lingua Franca) speakers continue to increase. The book will be of great interest to academics, researchers, and post-graduate students working in the fields of EFL and ESL.

The extraterrestrial girls meet their match when they arrive The School for Extraterrestrial Boys! The extraterrestrial girls are back! With their former school compromised, exposing Tara, Misako, Summer, and Kat, to possible danger from unknown alien forces, they all must relocate to a new hidden school--The School for Extraterrestrial Boys! Located on a hidden island in the arctic north, the new campus has a mysteriously warm summer climate, a beautiful lake, and dozens of sinister mysteries! The girls are staying in what appears to be summer cabins on the lake while going to school in the mysterious castle where the boys stay. This is all under the watchful eye of the boys' headmaster, Headmaster Stokes-an arrogant man with an unknown agenda and an obsession with Tara's people. Romance, magic, and near-death experiences are all part of a regular school day at the School for Extraterrestrial Girls.

Cement-based concrete has excellent properties as a construction material, and the raw materials of cement-rocks, and limestone and clay-are bountiful. Yet its production generates high quantities of CO2, making it a potentially unsustainable material. However, there are no alternatives to concrete and steel as basic methods for development of socioeconomic infrastructure at this time. Highlighting sustainability issues in the construction industry, The Sustainable Use of Concrete presents guidelines on how to move toward sustainable concrete construction. The book begins by clarifying the historic background and meaning of sustainability, after which it outlines areas that need to be considered in connection with sustainability in the concrete and construction field. It examines environmental, social and cultural, and economic aspects, then considers an evaluation system of sustainability. The authors include various tools and ISO standards, and then explore technologies for sustainability, with case studies and examples that promote understanding of current technologies. Although the construction sector, in the broadest sense, has come to recognize that infrastructure development over the past two centuries has been unsustainable, it has been slow to adjust. Comprehensive information and relevant practical guidance are very scarce. This book lays out a roadmap for creating a human-friendly and safe environment with low environmental burden.

The extraterrestrial girls meet their match when they arrive The School for Extraterrestrial Boys! The extraterrestrial girls are back! With their former school compromised, exposing Tara, Misako, Summer, and Kat, to possible danger from unknown alien forces, they all must relocate to a new hidden school--The School for Extraterrestrial Boys! Located on a hidden island in the arctic north, the new campus has a mysteriously warm summer climate, a beautiful lake, and dozens of sinister mysteries! The girls are staying in what appears to be summer cabins on the lake while going to school in the mysterious castle where the boys stay. This is all under the watchful eye of the boys' headmaster, Headmaster Stokes-an arrogant man with an unknown agenda and an obsession with Tara's people. Romance, magic, and near-death experiences are all part of a regular school day at the School for Extraterrestrial Girls.

Cement-based concrete has excellent properties as a construction material, and the raw materials of cement-rocks, and limestone and clay-are bountiful. Yet its production generates high quantities of CO2, making it a potentially unsustainable material. However, there are no alternatives to concrete and steel as basic methods for development of socioeconomic infrastructure at this time. Highlighting sustainability issues in the construction industry, The Sustainable Use of Concrete presents guidelines on how to move toward sustainable concrete construction.

The book begins by clarifying the historic background and meaning of sustainability, after which it outlines areas that need to be considered in connection with sustainability in the concrete and construction field. It examines environmental, social and cultural, and economic aspects, then considers an evaluation system of sustainability. The authors include various tools and ISO standards, and then explore technologies for sustainability, with case studies and examples that promote understanding of current technologies.

Although the construction sector, in the broadest sense, has come to recognize that infrastructure development over the past two centuries has been unsustainable, it has been slow to adjust. Comprehensive information and relevant practical guidance are very scarce. This book lays out a roadmap for creating a human-friendly and safe environment with low environmental burden.

This book proposes a new paradigm for English language teaching based on concepts from English for Specific Purposes (ESP) research and applications as well as from growing evidence relating pattern recognition to language learning ability. The contributors to the volume argue that learners should not try to become proficient all-around users of 'idealistic native-like' English, but instead should be realistic about what they need to acquire and how to go about achieving their specific goals. The book discusses the present situation by describing the status quo of English language education in Japan, taking into consideration recent trends of CLIL (content and language integrated learning), EMI (English medium instruction), and TBLT (task-based language teaching) as well as the work done on the Common European Framework of Reference for Languages (CEFR). It introduces new movements in ESP in Japan and in other Asian regions, covering topics ranging from genre analysis to corpus linguistics, and presents application examples of ESP practice in a range of educational situations in Japan from the graduate school level to elementary and middle school contexts. It also offers readers application examples of ESP practice in a range of business settings and expands the discussion to the global sphere where EAP and ESP are gaining importance as the number of ELF (English as a Lingua Franca) speakers continue to increase. The book will be of great interest to academics, researchers, and post-graduate students working in the fields of EFL and ESL.

Presents a comprehensive overview of governance in family enterprises including practical management knowledge in easy-to-use frameworks and interviews with renowned family enterprise owners and managers. Readers will benefit from the book's systematic approach and the opportunity to learn from the experience of other family enterprises.

Educating for Sustainable Development (ESD) approaches are holistic and interdisciplinary, values-driven, participatory, multi-method, locally relevant and emphasize critical thinking and problem-solving. This book explains how ESD approaches work in the Japanese context; their effects on different stakeholders; and their ultimate potential contribution to society in Japan. It considers ESD in both formal and informal education sectors, recognizing that even when classroom learning takes place it must be place-based and predicated on a specific community context. The book explores not only 'Why ESD', but why and how ESD in Japan has gained importance in the past decade and more recently in the wake of the triple disaster of March 2011. It considers how ESD can help Japan recover and adapt to disasters and take initiative in building more resilient and sustainable communities. This volume asks the questions: What are some examples of positive contributions by ESD to sustainability in Japan? What is the role of ESD in Japan in activating people to demand and work towards change? How can schools, universities and non-governmental organizations link with communities to strengthen civic awareness and community action? After an introduction that elucidates the roots and recent promotion of ESD in Japan, part one of this volume looks at the formal education sector in Japan, while part two examines community-based education and sustainability initiatives. The latter revisits the Tohoku region five years on from the events of March 2011, to explore recovery and revitalization efforts by schools, NGOs and residents. This is an invaluable book for postgraduate students, researchers, teachers and policy makers working on ESD.

This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry. Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested o nly natural products bearing one stereochemistry available in nature. As natural products and their enantiomers have identical physicochemical properties and different biological activities, mirror-image isomers of natural products are promising candidates for novel medicinal resources. In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. In the course of this process the NP843 enantiomer, which is the enantiomer of an -tocopherol derivative, was successfully identified as a novel MDM2-p53 interaction inhibitor. These results clearly show that a mirror-image library of chiral natural products represents an invaluable medicinal resource. Accordingly, the chemistry-based screening strategy described in this thesis will be of great interest to a broad range of chemists involved in natural product, medicinal, and synthetic chemistry.

The purpose of this book is to present the classical analytic function theory of several variables as a standard subject in a course of mathematics after learning the elementary materials (sets, general topology, algebra, one complex variable). This includes the essential parts of Grauert-Remmert's two volumes, GL227(236) (Theory of Stein spaces) and GL265 (Coherent analytic sheaves) with a lowering of the level for novice graduate students (here, Grauert's direct image theorem is limited to the case of finite maps).The core of the theory is "Oka's Coherence", found and proved by Kiyoshi Oka. It is indispensable, not only in the study of complex analysis and complex geometry, but also in a large area of modern mathematics. In this book, just after an introductory chapter on holomorphic functions (Chap. 1), we prove Oka's First Coherence Theorem for holomorphic functions in Chap. 2. This defines a unique character of the book compared with other books on this subject, in which the notion of coherence appears much later.The present book, consisting of nine chapters, gives complete treatments of the following items: Coherence of sheaves of holomorphic functions (Chap. 2); Oka-Cartan's Fundamental Theorem (Chap. 4); Coherence of ideal sheaves of complex analytic subsets (Chap. 6); Coherence of the normalization sheaves of complex spaces (Chap. 6); Grauert's Finiteness Theorem (Chaps. 7, 8); Oka's Theorem for Riemann domains (Chap. 8). The theories of sheaf cohomology and domains of holomorphy are also presented (Chaps. 3, 5). Chapter 6 deals with the theory of complex analytic subsets. Chapter 8 is devoted to the applications of formerly obtained results, proving Cartan-Serre's Theorem and Kodaira's Embedding Theorem. In Chap. 9, we discuss the historical development of "Coherence".It is difficult to find a book at this level that treats all of the above subjects in a completely self-contained manner. In the present volume, a number of classical proofs are improved and simplified, so that the contents are easily accessible for beginning graduate students.

In this book, leading international experts explore the emerging concept of the zero energy mass custom home (ZEMCH) - designed to meet the need for social, economic, and environmental sustainability - and provide all of the knowledge required for the delivery of zero energy mass customized housing and community developments in developed and developing countries. The coverage is wide ranging, progressing from explanation of the meaning of sustainable development to discussion of challenges and trends in mass housing, the advantages and disadvantages of prefabricated methods of construction, and the concepts of mass customization, mass personalization, and inclusive design. A chapter on energy use will aid the reader in designing and retrofitting housing to reduce energy demand and/or improve energy end-use efficiency. Passive design strategies and active technologies (especially solar) are thoroughly reviewed. Application of the ZEMCH construction criteria to new buildings and refurbishment of old houses is explained and the methods and value of building performance simulation, analyzed. The concluding chapter presents examples of ZEMCH projects from around the world, with discussion of marketing strategy, design, quality assurance, and delivery challenges. The book will be invaluable as a training/teaching tool for both students and industry partners.

This thesis mainly describes the development of a screening process for a mirror-image library of chiral natural products. It demonstrates how, by using mirror-image proteins for the screening of available natural products, unavailable mirror-image isomers of natural products can be screened in a mirror process. Moreover, as mirror-image isomers including target proteins and natural products are mainly prepared by means of chemical synthesis, the screening strategy presented here suggests the importance of organic chemistry. Natural products are commonly used as valuable resources for drug discovery. However, as they are mostly produced as single enantiomeric forms, researchers have tested o nly natural products bearing one stereochemistry available in nature. As natural products and their enantiomers have identical physicochemical properties and different biological activities, mirror-image isomers of natural products are promising candidates for novel medicinal resources. In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening process were achieved. In the course of this process the NP843 enantiomer, which is the enantiomer of an -tocopherol derivative, was successfully identified as a novel MDM2-p53 interaction inhibitor. These results clearly show that a mirror-image library of chiral natural products represents an invaluable medicinal resource. Accordingly, the chemistry-based screening strategy described in this thesis will be of great interest to a broad range of chemists involved in natural product, medicinal, and synthetic chemistry.

This volume is dedicated to the memory of Shoshichi Kobayashi, and gathers contributions from distinguished researchers working on topics close to his research areas. The book is organized into three parts, with the first part presenting an overview of Professor Shoshichi Kobayashi's career. This is followed by two expository course lectures (the second part) on recent topics in extremal Kahler metrics and value distribution theory, which will be helpful for graduate students in mathematics interested in new topics in complex geometry and complex analysis. Lastly, the third part of the volume collects authoritative research papers on differential geometry and complex analysis. Professor Shoshichi Kobayashi was a recognized international leader in the areas of differential and complex geometry. He contributed crucial ideas that are still considered fundamental in these fields. The book will be of interest to researchers in the fields of differential geometry, complex geometry, and several complex variables geometry, as well as to graduate students in mathematics.

A collection of new reviews and protocols from leading experts in cell cycle regulation, Cell Cycle Control: Mechanisms and Protocols, Second Edition presents a comprehensive guide to recent technical and theoretical advancements in the field. Beginning with the overviews of various cell cycle regulations, this title presents the most current protocols and state-of-the-art techniques used to generate latest findings in cell cycle regulation, such as protocols to analyze cell cycle events and molecules. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Cell Cycle Control: Mechanisms and Protocols, Second Edition will be a valuable resource for a wide audience, ranging from the experienced cell cycle researchers looking for new approaches to the junior graduate students giving their first steps in cell cycle research.

The aim of this book is to provide a comprehensive account of higher dimensional Nevanlinna theory and its relations with Diophantine approximation theory for graduate students and interested researchers. This book with nine chapters systematically describes Nevanlinna theory of meromorphic maps between algebraic varieties or complex spaces, building up from the classical theory of meromorphic functions on the complex plane with full proofs in Chap. 1 to the current state of research. Chapter 2 presents the First Main Theorem for coherent ideal sheaves in a very general form. With the preparation of plurisubharmonic functions, how the theory to be generalized in a higher dimension is described. In Chap. 3 the Second Main Theorem for differentiably non-degenerate meromorphic maps by Griffiths and others is proved as a prototype of higher dimensional Nevanlinna theory. Establishing such a Second Main Theorem for entire curves in general complex algebraic varieties is a wide-open problem. In Chap. 4, the Cartan-Nochka Second Main Theorem in the linear projective case and the Logarithmic Bloch-Ochiai Theorem in the case of general algebraic varieties are proved. Then the theory of entire curves in semi-abelian varieties, including the Second Main Theorem of Noguchi-Winkelmann-Yamanoi, is dealt with in full details in Chap. 6. For that purpose Chap. 5 is devoted to the notion of semi-abelian varieties. The result leads to a number of applications. With these results, the Kobayashi hyperbolicity problems are discussed in Chap. 7. In the last two chapters Diophantine approximation theory is dealt with from the viewpoint of higher dimensional Nevanlinna theory, and the Lang-Vojta conjecture is confirmed in some cases. In Chap. 8 the theory over function fields is discussed. Finally, in Chap. 9, the theorems of Roth, Schmidt, Faltings, and Vojta over number fields are presented and formulated in view of Nevanlinna theory with results motivated by those in Chaps. 4, 6, and 7.

In this book, leading international experts explore the emerging concept of the zero energy mass custom home (ZEMCH) - designed to meet the need for social, economic, and environmental sustainability - and provide all of the knowledge required for the delivery of zero energy mass customized housing and community developments in developed and developing countries. The coverage is wide ranging, progressing from explanation of the meaning of sustainable development to discussion of challenges and trends in mass housing, the advantages and disadvantages of prefabricated methods of construction, and the concepts of mass customization, mass personalization, and inclusive design. A chapter on energy use will aid the reader in designing and retrofitting housing to reduce energy demand and/or improve energy end-use efficiency. Passive design strategies and active technologies (especially solar) are thoroughly reviewed. Application of the ZEMCH construction criteria to new buildings and refurbishment of old houses is explained and the methods and value of building performance simulation, analyzed. The concluding chapter presents examples of ZEMCH projects from around the world, with discussion of marketing strategy, design, quality assurance, and delivery challenges. The book will be invaluable as a training/teaching tool for both students and industry partners.

This volume is dedicated to the memory of Shoshichi Kobayashi, and gathers contributions from distinguished researchers working on topics close to his research areas. The book is organized into three parts, with the first part presenting an overview of Professor Shoshichi Kobayashi's career. This is followed by two expository course lectures (the second part) on recent topics in extremal Kahler metrics and value distribution theory, which will be helpful for graduate students in mathematics interested in new topics in complex geometry and complex analysis. Lastly, the third part of the volume collects authoritative research papers on differential geometry and complex analysis. Professor Shoshichi Kobayashi was a recognized international leader in the areas of differential and complex geometry. He contributed crucial ideas that are still considered fundamental in these fields. The book will be of interest to researchers in the fields of differential geometry, complex geometry, and several complex variables geometry, as well as to graduate students in mathematics.

Creating clinical guidelines is a modern trend. Published studies pertaining to a given theme are collected, their credibility evaluated, and then treatment options in the form of evidence-based guidelines are offered. There are a number of guidelines for the treatment of thyroid tumors that have established positions in clinical practice in North America and in Western European countries. In Japan, however, where radioisotope facilities are of limited availability, treatment plans for differentiated thyroid cancer differ considerably from those of America and Europe, and the associated clinical guidelines need modification before they can be adopted. In addition, although thyroid tumor is a common disease in endocrine practice, its management can differ even among specialists. Thus, a Japanese clinical guideline for the treatment of thyroid tumor was desired by many clinicians. As a combination of evidence-based and consensus-based guidelines for the treatment of thyroid tumor, this book offers alternatives to conventional approaches in the West. Ultimately, the authors hope the guideline will lead to the best possible treatment for patients all over the world in the not-distant future.

A collection of new reviews and protocols from leading experts in cell cycle regulation, Cell Cycle Control: Mechanisms and Protocols, Second Edition presents a comprehensive guide to recent technical and theoretical advancements in the field. Beginning with the overviews of various cell cycle regulations, this title presents the most current protocols and state-of-the-art techniques used to generate latest findings in cell cycle regulation, such as protocols to analyze cell cycle events and molecules. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Cell Cycle Control: Mechanisms and Protocols, Second Edition will be a valuable resource for a wide audience, ranging from the experienced cell cycle researchers looking for new approaches to the junior graduate students giving their first steps in cell cycle research.

The aim of this book is to provide a comprehensive account of higher dimensional Nevanlinna theory and its relations with Diophantine approximation theory for graduate students and interested researchers. This book with nine chapters systematically describes Nevanlinna theory of meromorphic maps between algebraic varieties or complex spaces, building up from the classical theory of meromorphic functions on the complex plane with full proofs in Chap. 1 to the current state of research. Chapter 2 presents the First Main Theorem for coherent ideal sheaves in a very general form. With the preparation of plurisubharmonic functions, how the theory to be generalized in a higher dimension is described. In Chap. 3 the Second Main Theorem for differentiably non-degenerate meromorphic maps by Griffiths and others is proved as a prototype of higher dimensional Nevanlinna theory. Establishing such a Second Main Theorem for entire curves in general complex algebraic varieties is a wide-open problem. In Chap. 4, the Cartan-Nochka Second Main Theorem in the linear projective case and the Logarithmic Bloch-Ochiai Theorem in the case of general algebraic varieties are proved. Then the theory of entire curves in semi-abelian varieties, including the Second Main Theorem of Noguchi-Winkelmann-Yamanoi, is dealt with in full details in Chap. 6. For that purpose Chap. 5 is devoted to the notion of semi-abelian varieties. The result leads to a number of applications. With these results, the Kobayashi hyperbolicity problems are discussed in Chap. 7. In the last two chapters Diophantine approximation theory is dealt with from the viewpoint of higher dimensional Nevanlinna theory, and the Lang-Vojta conjecture is confirmed in some cases. In Chap. 8 the theory over function fields is discussed. Finally, in Chap. 9, the theorems of Roth, Schmidt, Faltings, and Vojta over number fields are presented and formulated in view of Nevanlinna theory with results motivated by those in Chaps. 4, 6, and 7.

Creating clinical guidelines is a modern trend. Published studies pertaining to a given theme are collected, their credibility evaluated, and then treatment options in the form of evidence-based guidelines are offered. There are a number of guidelines for the treatment of thyroid tumors that have established positions in clinical practice in North America and in Western European countries. In Japan, however, where radioisotope facilities are of limited availability, treatment plans for differentiated thyroid cancer differ considerably from those of America and Europe, and the associated clinical guidelines need modification before they can be adopted. In addition, although thyroid tumor is a common disease in endocrine practice, its management can differ even among specialists. Thus, a Japanese clinical guideline for the treatment of thyroid tumor was desired by many clinicians. As a combination of evidence-based and consensus-based guidelines for the treatment of thyroid tumor, this book offers alternatives to conventional approaches in the West. Ultimately, the authors hope the guideline will lead to the best possible treatment for patients all over the world in the not-distant future.

This textbook is for those who want to learn linear algebra from the basics. After a brief mathematical introduction, it provides the standard curriculum of linear algebra based on an abstract linear space. It covers, among other aspects: linear mappings and their matrix representations, basis, and dimension; matrix invariants, inner products, and norms; eigenvalues and eigenvectors; and Jordan normal forms. Detailed and self-contained proofs as well as descriptions are given for all theorems, formulas, and algorithms. A unified overview of linear structures is presented by developing linear algebra from the perspective of functional analysis. Advanced topics such as function space are taken up, along with Fourier analysis, the Perron–Frobenius theorem, linear differential equations, the state transition matrix and the generalized inverse matrix, singular value decomposition, tensor products, and linear regression models. These all provide a bridge to more specialized theories based on linear algebra in mathematics, physics, engineering, economics, and social sciences. Python is used throughout the book to explain linear algebra. Learning with Python interactively, readers will naturally become accustomed to Python coding.  By using Python’s libraries NumPy, Matplotlib, VPython, and SymPy,  readers can easily perform large-scale matrix calculations, visualization of calculation results, and symbolic computations.  All the codes in this book can be executed on both Windows and macOS and also on Raspberry Pi.

In the Teichm ller theory of Riemann surfaces, besides the classical theory of quasi-conformal mappings, vari- ous approaches from differential geometry and algebraic geometry have merged in recent years. Thus the central subject of "Complex Structure" was a timely choice for the joint meetings in Katata and Kyoto in 1989. The invited participants exchanged ideas on different approaches to related topics in complex geometry and mapped out the prospects for the next few years of research.